Fenben lab fenbendazol is an antiparasitic drug that has been repurposed to treat certain cancers. It has been shown to target and inhibit microtubule-associated tubulin polymerization, and to exert antitumor effects in various cancer cell types. However, fenbendazole’s safety and tolerability in humans is not well established. In this study, we report the case of an 80-year-old woman with advanced nonsmall-cell lung cancer who received information on fenbendazole’s antitumor activity through social media and orally self-administered it for a month before experiencing severe liver injury.
Our results show that fenbendazole can be safely delivered into the cells by mPEG-b-PCL micelles formulated with rapamycin. The micelles had good stability in solution and exhibited high PDI (Figure 2A). In addition, the mPEG-b-PCL/FEN/RAPA complex was able to inhibit the growth of human cancer cells without altering the cellular microtubule structure.
Fenbendazole is an oral medication that treats a variety of parasites, including roundworms, hookworms, whipworms, lungworms, and certain types of tapeworms in cats. It is also used ‘off label’ in veterinary medicine to treat parasites in laboratory animals, such as rodents, rabbits, and mice. It comes in the form of granules or liquid suspension and is administered by mouth. It should always be given with food to reduce gastrointestinal upset. This drug is available as a generic under the brand name Panacur, and has been used to eradicate pinworm infections in laboratory rodent colonies. For more information on this and other pet medications, see the article in Contemp Top Lab Anim Sci.fenben lab fenbendazol